Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial.

ABSTRACT:

Background

A few studies have evaluated the impact of clinical trial results on practice in paediatric cardiology. The Infant Single Ventricle (ISV) Trial results published in 2010 did not support routine use of the angiotensin-converting enzyme inhibitor enalapril in infants with single-ventricle physiology. We sought to assess the influence of these findings on clinical practice.

Methods

A web-based survey was distributed via e-mail to over 2000 paediatric cardiologists, intensivists, cardiothoracic surgeons, and cardiac advance practice nurses during three distribution periods. The results were analysed using McNemar's test for paired data and Fisher's exact test.

Results

The response rate was 31.5% (69% cardiologists and 65% with >10 years of experience). Among re

SUBMITTER: Zak V 

PROVIDER: S-EPMC5721352 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature