Activin A is a prominent autocrine regulator of hepatocyte growth arrest.

ABSTRACT: Activin A, a multifunctional cytokine, plays an important role in hepatocyte growth suppression and is involved in liver size control. The present study was aimed to determine the cell location of activin A in the normal rat liver microenvironment and the contribution of activin A signaling to the hepatocyte phenotype to obtain insight into molecular mechanisms. Immunohistochemical and in situ hybridization analyses identified hepatocytes as the major activin A-positive cell population in normal liver and identified mast cells as an additional activin A source. To investigate paracrine and autocrine activin A-stimulated effects, hepatocytes were cocultured with engineered activin A-secreting cell lines (RF1, TL8) or transduced with an adeno-associated virus vector encoding activin β

SUBMITTER: Haridoss S 

PROVIDER: S-EPMC5721463 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature