Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs.

ABSTRACT:

Background

Next-generation metagenomic sequencing (NGMS) has opened new frontiers in microbial discovery but has been clinically characterized in only a few settings.

Objective

To explore the plasma virome of persons who inject drugs and to characterize the sensitivity and accuracy of NGMS compared with quantitative clinical standards.

Design

Longitudinal and cross-sectional studies.

Setting

A clinical trial (ClinicalTrials.gov: NCT01285050) and a well-characterized cohort study of persons who have injected drugs.

Participants

Persons co-infected with hepatitis C virus (HCV) and HIV.

Measurements

Viral nucleic acid in plasma by NGMS and quantitative polymerase chain reaction (PCR).

Results

Next-generation metagenomic sequencing generated a

SUBMITTER: Kandathil AJ 

PROVIDER: S-EPMC5721525 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature