Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases.

ABSTRACT: The tripartite motif (TRIM) gene family is a highly conserved group of E3 ubiquitin ligase proteins that can establish substrate specificity for the ubiquitin-proteasome complex and also have proteasome-independent functions. While several family members were studied previously, it is relatively recent that over 80 genes, based on sequence homology, were grouped to establish the TRIM gene family. Functional studies of various TRIM genes linked these proteins to modulation of inflammatory responses showing that they can contribute to a wide variety of disease states including cardiovascular, neurological and musculoskeletal diseases, as well as various forms of cancer. Given the fundamental role of the ubiquitin-proteasome complex in protein turnover and the importance of this regulation in

SUBMITTER: Gushchina LV 

PROVIDER: S-EPMC5721676 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature