Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta.

ABSTRACT: Medial calcification in the human aorta accumulates during aging and is known to be aggravated in several diseases. Atherosclerosis, another major cause of cardiovascular calcification, shares some common aggravators. However, the mechanisms of cardiovascular calcification remain poorly understood. To elucidate the relationship between medial aortic calcification and atherosclerosis, we characterized the cross-sectional distributions of the predominant minerals in aortic tissue, apatite and whitlockite, and the associated extracellular matrix. We also compared the cellular changes between atherosclerotic and nonatherosclerotic human aortic tissues. This was achieved through the development of Raman spectroscopy imaging methods that adapted algorithms to distinguish between the major biomol

SUBMITTER: You AYF 

PROVIDER: S-EPMC5721727 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature