Regional Validation and Recalibration of Clinical Predictive Models for Patients With Acute Heart Failure.

ABSTRACT: Heart failure clinical practice guidelines recommend applying validated clinical predictive models (CPMs) to support decision making. While CPMs are now widely available, the generalizability of heart failure CPMs is largely unknown. We identified CPMs derived in North America that predict mortality for patients with acute heart failure and validated these models in different world regions to assess performance in a contemporary international clinical trial (N=4133) of patients with acute heart failure treated with guideline-directed medical therapy. We performed independent external validations of 3 CPMs predicting in-hospital mortality, 60-day mortality, and 1-year mortality, respectively. CPM discrimination decreased in all regional validation cohorts. The median change in area under th

SUBMITTER: Wessler BS 

PROVIDER: S-EPMC5721739 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature