Endothelial Progenitor Cell Biology and Vascular Recovery Following Transradial Cardiac Catheterization.

ABSTRACT: Transradial catheterization is associated with radial artery injury and vasomotor dysfunction and represents an accessible model of acute vascular injury in humans. We characterized vascular injury and functional recovery to understand the role of circulating endothelial progenitor cells in vascular repair. In 50 patients (aged 64±10 years, 70% male) undergoing transradial cardiac catheterization, radial artery injury was assessed by optical coherence tomography and examination of explanted vascular sheaths. Flow- and nitrate-mediated dilatation of the radial artery was assessed in both arms at baseline, at 24 hours, and at 1, 4, and 12 weeks. Circulating endothelial progenitor cell populations were quantified using flow cytometry. Late endothelial outgrowth colonies were isolated and exam

SUBMITTER: Mitchell A 

PROVIDER: S-EPMC5721759 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature