Genetic Variation at the <i>ADAMTS7</i> Locus is Associated With Reduced Severity of Coronary Artery Disease.

ABSTRACT:

Background

Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest that ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using histological, angiographic, and clinical outcomes data.

Methods and results

The lead CAD-associated single-nucleotide polymorphism rs3825807 at the ADAMTS7 locus was genotyped. The G allele (reduced ADAMTS7 function) was associated with a smaller fibrous cap (P=0.017) and a smaller percentage area of α-actin (smooth muscle cell marker) in the intima (P=0.017), but was not associated with calcification or plaque thickness, following ex vivo immunohisto

SUBMITTER: Chan K 

PROVIDER: S-EPMC5721775 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature