Hypertension in Obese Black Women is Not Caused by Increased Sympathetic Vascular Tone.

ABSTRACT:

Background

Black women have one of the highest prevalence rates of hypertension and obesity in the United States. We previously reported that sympathetic activation induced by obesity is a significant contributor to hypertension in white patients. It is unknown whether sympathetic activity similarly contributes to hypertension in obese black women.

Methods and results

We studied 42 obese women (16 white, body mass index 36±4 kg/m², 44% with hypertension; 26 black, body mass index 35±4 kg/m², 46% with hypertension). Antihypertensive medications were discontinued for 2 weeks before the day of the study. All patients underwent complete autonomic blockade with trimethaphan at a dosage of 4 mg/min. Resting sympathetic activity determined from muscle sympathe

SUBMITTER: Marinos A 

PROVIDER: S-EPMC5721777 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature