Time in Therapeutic Range, as a Determinant of All-Cause Mortality in Patients With Hypertension.

ABSTRACT: Accumulating evidence indicates that reducing systolic blood pressure (BP) to <140 mm Hg improves health outcomes; however, an optimal level has not yet been determined. Many population studies or post hoc analyses suggest a target systolic BP between 120 and 140 mm Hg with increased risk above and below that range. We tested the hypothesis that consistent control of systolic BP between 120 and 140 mm Hg-time in therapeutic range-is a strong determinant of all-cause mortality among US veterans. A total of 689 051 individuals from 15 Veterans Administration Medical Centers were followed over a 10-year period. Participants were classified as hypertensive, intermediate hypertensive, and normotensive according to the number of elevated BP recordings (>3, 1 or 2, and none, respectively). Time w

SUBMITTER: Doumas M 

PROVIDER: S-EPMC5721788 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature