DBZ (Danshensu Bingpian Zhi), a Novel Natural Compound Derivative, Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice.

ABSTRACT:

Background

DBZ (Danshensu Bingpian Zhi), a synthetic derivative of a natural compound found in traditional Chinese medicine, has been reported to suppress lipopolysaccharide-induced macrophage activation and lipid accumulation in vitro. The aim of this study was to assess whether DBZ could attenuate atherosclerosis at early and advanced stages.

Methods and results

The effects of DBZ on the development of atherosclerosis were studied using apolipoprotein E-deficient (apoE^-/-) mice. For early treatment, 5-week-old apoE^-/- mice were fed a Western diet and treated daily by oral gavage with or without DBZ or atorvastatin for 10 weeks. For advanced treatment, 5-week-old apoE^-/- mice were fed a Western diet for 10 weeks to induce atherosclerosis, an

SUBMITTER: Wang J 

PROVIDER: S-EPMC5721843 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature