Peptidyl-Prolyl Isomerase 1 Regulates Ca²⁺ Handling by Modulating Sarco(Endo)Plasmic Reticulum Calcium ATPase and Na²⁺/Ca²⁺ Exchanger 1 Protein Levels and Function.

ABSTRACT:

Background

Aberrant Ca²⁺ handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca²⁺ handling is essential for the development of strategies to blunt pathological changes in calcium dynamics. The peptidyl-prolyl cis-trans isomerase peptidyl-prolyl isomerase 1 (Pin1) is a critical mediator of myocardial hypertrophy development and cardiac progenitor cell cycle. However, the influence of Pin1 on calcium cycling regulation has not been explored. On the basis of these findings, the aim of this study is to define Pin1 as a novel modulator of Ca²⁺ handling, with implications for improving myocardial contractility and potential for ameliorating development of heart failure.

Method

SUBMITTER: Sacchi V 

PROVIDER: S-EPMC5721875 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature