Multifunctional Cu₃₉S₂₈ Hollow Nanopeanuts for In Vivo Targeted Photothermal Chemotherapy.

ABSTRACT: Actively targeted hollow nanoparticles may play key roles in precise anti-cancer therapy. Here, unique Cu₃₉S₂₈ hollow nanopeanuts (HNPs) were synthesized via a facile one-step method and the formation mechanism was illustrated. The as-synthesized Cu₃₉S₂₈ HNPs exhibit outstanding photothermal conversion efficiency (41.1%) and drug storage capacity (DOX, 99.5 %). At the same time, the DOX drug loading nanocomposites have shown great sensitive response of release to either pH value or near infrared ray (NIR). In particular, the folic acid (FA) can easily conjugate with the synthesized Cu₃₉S₂₈ HNPs without further modification to get a targeted effect. The FA modified Cu₃₉S₂₈ HNPs showed an efficient

SUBMITTER: Li L 

PROVIDER: S-EPMC5722029 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature