High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial.

ABSTRACT:

Introduction

Acute pancreatitis (AP) is an inflammatory disease with no specific treatment. Mitochondrial injury followed by ATP depletion in both acinar and ductal cells is a recently discovered early event in its pathogenesis. Importantly, preclinical research has shown that intracellular ATP delivery restores the physiological function of the cells and protects from cell injury, suggesting that restoration of energy levels in the pancreas is therapeutically beneficial. Despite several high quality experimental observations in this area, no randomised trials have been conducted to date to address the requirements for energy intake in the early phase of AP.

Methods/design

This is a randomised controlled two-arm double-blind multicentre trial. Patients with AP will be random

SUBMITTER: Marta K 

PROVIDER: S-EPMC5722094 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature