Universal or targeted approach to prevent the transmission of extended-spectrum beta-lactamase-producing Enterobacteriaceae in intensive care units: a cost-effectiveness analysis.

ABSTRACT:

Objective

Several control strategies have been used to limit the transmission of multidrug-resistant organisms in hospitals. However, their implementation is expensive and effectiveness of interventions for the control of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) spread is controversial. Here, we aim to assess the cost-effectiveness of hospital-based strategies to prevent ESBL-PE transmission and infections.

Design

Cost-effectiveness analysis based on dynamic, stochastic transmission model over a 1-year time horizon.

Patients and setting

Patients hospitalised in a hypothetical 10-bed intensive care unit (ICU) in a high-income country.

Interventions

Base case scenario compared with (1) universal strategies (eg, improvement of

SUBMITTER: Kardas-Sloma L 

PROVIDER: S-EPMC5722099 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature