Tissue-based biomarkers in prostate cancer.

ABSTRACT:

Introduction

Prostate cancer is a heterogeneous disease. Existing risk stratification tools based on standard clinlicopathologic variables (prostate specific antigen [PSA], Gleason score, and tumor stage) provide a modest degree of predictive ability. Advances in high-throughput sequencing has led to the development of several novel tissue-based biomarkers that can improve prognostication in prostate cancer management.

Areas covered

The authors review commercially-available, tissue-based biomarker assays that improve upon existing risk-stratification tools in several areas of prostate cancer management, including the appropriateness of active surveillance and aiding in decision making regarding the use of adjuvant therapy. Additionally, some of the obstacles to the widesprea

SUBMITTER: Clinton TN 

PROVIDER: S-EPMC5722240 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature