Synthesis of cananodine by intramolecular epoxide opening.

ABSTRACT: Cananodine is a guaipyridine alkaloid with activity against liver cancer. Cananodine was synthesized using a remarkable intramolecular opening of a trisubstituted epoxide as the key step in construction of the seven-membered carbocycle of the target. The epoxide opening strategy allows all four stereoisomers of cananodine to be prepared.

SUBMITTER: Shelton P 

PROVIDER: S-EPMC5722248 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature