Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment.

ABSTRACT: BACKGROUND Despite its recognised toxicity, antimonial therapy continues to be the first-line drug for cutaneous leishmaniasis (CL) treatment. Intralesional administration of meglumine antimoniate (MA) represents an alternative that could reduce the systemic absorption of the drug and its side effects. OBJECTIVES This study aims to validate the standard operational procedure (SOP) for the intralesional infiltration of MA for CL therapy as the first step before the assessment of efficacy and safety related to the procedure. METHODS The SOP was created based on 21 trials retrieved from the literature, direct monitoring of the procedure and consultation with experts. This script was submitted to a formal computer-aided inspection to identify readability, clarity, omission, redundancy and unne

SUBMITTER: Silva RED 

PROVIDER: S-EPMC5722261 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature