PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development.

ABSTRACT: CD68+ tumor-associated macrophages (TAMs) are pro-tumorigenic, pro-angiogenic and are associated with decreased survival rates in patients with cancer, including breast cancer. Non-specific models of macrophage ablation reduce the number of TAMs and limit the development of mammary tumors. However, the lack of specificity and side effects associated with these models compromise their reliability. We hypothesized that specific and controlled macrophage depletion would provide precise data on the effects of reducing TAM numbers on tumor development. In this study, the MacLow mouse model of doxycycline-inducible and selective CD68+ macrophage depletion was crossed with the murine mammary tumor virus (MMTV)-Polyoma virus middle T antigen (PyMT) mouse model of spontaneous ductal breast adenocar

SUBMITTER: Rumney RMH 

PROVIDER: S-EPMC5722323 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature