Riemerella anatipestifer M949_0459 gene is responsible for the bacterial resistance to tigecycline.

ABSTRACT: Based on its important role in last-line therapeutics against multidrug-resistant bacteria, tigecycline has been increasingly important in treating infections. However, mounting reports on tigecycline-resistant bacterial strains isolated from different sources are of concern, and molecular mechanisms regarding tigecycline resistance are poorly understood. Riemerella anatipestifer is a Gram-negative, non-motile, non-spore-forming, rod-shaped bacterium, which causes fibrinous pericarditis, perihepatitis, and meningitis in infected ducks. We previously constructed a random transposon mutant library using Riemerella anatipestifer strain CH3, in present study, we described that Riemerella anatipestifer M949_0459 gene is responsible for the bacterial resistance to tigecyclin

SUBMITTER: Li T 

PROVIDER: S-EPMC5722508 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature