Association of single-nucleotide polymorphisms in the RAGE gene and its gene- environment interactions with diabetic nephropathy in Chinese patients with type 2 diabetes.

ABSTRACT:

Aims

To investigate the association of several single nucleotide polymorphisms (SNPs) within RAGE gene and additional gene- smoking interaction with diabetic nephropathy (DN) risk in Chinese patients with type 2 diabetes mellitus (T2DM).

Methods

A total of 865 participants (570 males, 295 females) were selected, including 430 T2DM complicated DN patients and 435 controls (T2DM patients without DN). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Logistic regression was performed to investigate impact of 4 SNPs within RAGE gene, additional gene- smoking interaction on DN risk.

Results

DN risk was significantly higher in carriers with the C allele of rs1800625 than those wi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5722530 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature