CYP19A1 polymorphisms associated with coronary artery disease and circulating sex hormone levels in a Chinese population.

ABSTRACT:

Background

The relationship between CYP19A1 genetic polymorphisms and coronary artery disease (CAD) remains unclear. Thus, the aim of the present study was to investigate the association of CYP19A1 genetic polymorphisms with CAD in Han and Uygur populations and to characterize the association between the levels of sex hormones and aromatase with single-nucleotide polymorphisms (SNPs) in CYP19A1 genes in Chinese women.

Results

There were significant differences in the genotype distributions of rs2236722 and rs4646 between CAD patients and control subjects in the Uygur population. The rs4646 was found to be associated with CAD in the dominant model (CC vs. CA + AA) and the additive model (CA vs. CC + AA) (both P ≤ 0.001). The difference remained statistically significan

SUBMITTER: Meng Y 

PROVIDER: S-EPMC5722548 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature