Analysis of molecular evolution of nucleocapsid protein in Newcastle disease virus.

ABSTRACT: The present study investigated the molecular evolution of nucleocapsid protein (NP) in different Newcastle disease virus (NDV) genotypes. The evolutionary timescale and rate were estimated using the Bayesian Markov chain Monte Carlo (MCMC) method. The p-distance, Bayesian skyline plot (BSP), and positively selected sites were also analyzed. The MCMC tree indicated that NDV diverged about 250 years ago with a rapid evolution rate (1.059 × 10^-2 substitutions/site/year) and that different NDV genotypes formed three lineages. The p-distance results reflected the great genetic diversity of NDV. BSP analysis suggested that the effective population size of NDV has been increasing since 2000 and that the basic reproductive number (R₀) of NDV ranged from 1.003 to 1.006. The ab

SUBMITTER: Fan W 

PROVIDER: S-EPMC5722550 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature