Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition.

ABSTRACT: Hyperthermia - application of supra-physiological temperatures to cells, tissues or organs - is a pleiotropic treatment that affects most aspects of cellular metabolism, but its effects on DNA are of special interest in the context of cancer research and treatment. Hyperthermia inhibits repair of various DNA lesions, including double-strand breaks (DSBs), making it a powerful radio- and chemosensitizer, with proven clinical efficacy in therapy of various types of cancer, including tumors of head and neck, bladder, breast and cervix. Among the challenges for hyperthermia-based therapies are the transient character of its effects, the technical difficulties in maintaining uniformly elevated tumor temperature and the acquisition of thermotolerance. Approaches to reduce or eliminate these chal

SUBMITTER: Vriend LEM 

PROVIDER: S-EPMC5722578 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature