The impact of bottlenecks on microbial survival, adaptation, and phenotypic switching in host-pathogen interactions.

ABSTRACT: Microbial pathogens and viruses can often maintain sufficient population diversity to evade a wide range of host immune responses. However, when populations experience bottlenecks, as occurs frequently during initiation of new infections, pathogens require specialized mechanisms to regenerate diversity. We address the evolution of such mechanisms, known as stochastic phenotype switches, which are prevalent in pathogenic bacteria. We analyze a model of pathogen diversification in a changing host environment that accounts for selective bottlenecks, wherein different phenotypes have distinct transmission probabilities between hosts. We show that under stringent bottlenecks, such that only one phenotype can initiate new infections, there exists a threshold stochastic switching rate below which

SUBMITTER: Moxon R 

PROVIDER: S-EPMC5722657 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature