PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy.

ABSTRACT:

Rationale

Pregnancy profoundly alters maternal physiology. The heart hypertrophies during pregnancy, but its metabolic adaptations, are not well understood.

Objective

To determine the mechanisms underlying cardiac substrate use during pregnancy.

Methods and results

We use here ¹³C glucose, ¹³C lactate, and ¹³C fatty acid tracing analyses to show that hearts in late pregnant mice increase fatty acid uptake and oxidation into the tricarboxylic acid cycle, while reducing glucose and lactate oxidation. Mitochondrial quantity, morphology, and function do not seem altered. Insulin signaling seems intact, and the abundance and localization of the major fatty acid and glucose transporters, CD36 (cluster of differentiation 36) and GLUT4 (glucos

SUBMITTER: Liu LX 

PROVIDER: S-EPMC5722682 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature