Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study.

ABSTRACT:

Introduction

The identification of novel biomarkers associated with Alzheimer's disease (AD) could provide key biological insights and permit targeted preclinical prevention. We investigated circulating metabolites associated with incident dementia and AD using metabolomics.

Methods

Plasma levels of 217 metabolites were assessed in 2067 dementia-free Framingham Offspring Cohort participants (mean age = 55.9 ± 9.7 years; 52.4% women). We studied their associations with future dementia and AD risk in multivariate Cox models.

Results

Ninety-three participants developed incident dementia (mean follow-up = 15.6 ± 5.2 years). Higher plasma anthranilic acid levels were associated with greater risk of dementia (hazard ratio [HR] = 1.40; 95% confidence interval [CI] = [1.15-1.

SUBMITTER: Chouraki V 

PROVIDER: S-EPMC5722716 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature