Clinical and Preclinical Advances in Gastroenteropancreatic Neuroendocrine Tumor Therapy.

ABSTRACT: The molecular events leading to gastroenteropancreatic neuroendocrine tumor (GEP-NET) formation are largely unknown. Over the past decades, systemic chemotherapies have been replaced by therapies directed at particular molecular targets such as the somatostatin receptors, mTOR complexes or proangiogenic molecules. These approaches have demonstrated some success in subtypes of this heterogeneous tumor group, but responses are still widely varied. This review highlights the clinical trials ongoing for neuroendocrine tumors (NETs) and includes emerging immunotherapy, which holds great promise for NETs based on successes in other tumor types. Current avenues of preclinical research, including Notch and PI3K/AKT, will lead to additional targeted therapies based on genome-wide studies that have

SUBMITTER: Crabtree JS 

PROVIDER: S-EPMC5722794 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature