Polymorphisms in JMJD1C are associated with pubertal onset in boys and reproductive function in men.

ABSTRACT: JMJD1C, a member of the Jumonji-domain containing histone demethylases protein family, has been associated with levels of sex-hormone binding globulin (SHBG) and testosterone in men, and knock-out rodent models show age-dependent infertility. The objective of this study was to investigate whether single nucleotide polymorphisms (SNPs) nearby JMJD1C are associated with pubertal onset in boys and with male reproduction. 671 peri-pubertal boys, 1,027 young men, 315 fertile men, and 252 infertile men were genotyped for two JMJD1C SNPs (rs7910927 and rs10822184). rs7910927 and rs10822184 showed high linkage. Boys with the rs7910927 TT genotype entered puberty 3.6 months earlier than their peers (p = 2.5 × 10^-2). In young men, the number of T alleles was associated with decreased leve

SUBMITTER: Morup N 

PROVIDER: S-EPMC5722903 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature