Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism.

ABSTRACT: Specialized metabolic enzymes and metabolite diversity evolve through a variety of mechanisms including promiscuity, changes in substrate specificity, modifications of gene expression and gene duplication. For example, gene duplication and substrate binding site changes led to the evolution of the glucosinolate biosynthetic enzyme, AtIPMDH1, from a Leu biosynthetic enzyme. BAHD acyltransferases illustrate how enzymatic promiscuity leads to metabolite diversity. The examples 4-coumarate:CoA ligase and aromatic acid methyltransferases illustrate how promiscuity can potentiate the evolution of these specialized metabolic enzymes.

SUBMITTER: Leong BJ 

PROVIDER: S-EPMC5723210 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature