Regulatory effects of IL-15 on allergen-induced airway obstruction.

ABSTRACT:

Background

Airway obstruction is a physiologic feature of asthma, and IL-15 might have an important role in asthma pathogenesis.

Objective

We tested the hypothesis that regulation of IL-15 is critical for preservation of allergen-induced airway hyperresponsiveness (AHR), airway resistance, and compliance in response to methacholine.

Methods

Airway inflammation, AHR, resistance, and compliance were assessed in Il15 gene-deficient mice and IL-15-overexpressing mice in an allergen-induced murine model of asthma. We assessed eosinophil numbers by using anti-major basic protein immunostaining, goblet cell hyperplasia by using periodic acid-Schiff staining, and cytokine and chemokine levels by performing quantitative PCR and ELISA.

Results

We made a novel observation

SUBMITTER: Venkateshaiah SU 

PROVIDER: S-EPMC5723242 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature