Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex.

ABSTRACT: The successful planning and execution of adaptive behaviors in mammals may require long-range coordination of neural networks throughout cerebral cortex. The neuronal implementation of signals that could orchestrate cortex-wide activity remains unclear. Here, we develop and apply methods for cortex-wide Ca²⁺ imaging in mice performing decision-making behavior and identify a global cortical representation of task engagement encoded in the activity dynamics of both single cells and superficial neuropil distributed across the majority of dorsal cortex. The activity of multiple molecularly defined cell types was found to reflect this representation with type-specific dynamics. Focal optogenetic inhibition tiled across cortex revealed a crucial role for frontal cortex in triggering t

SUBMITTER: Allen WE 

PROVIDER: S-EPMC5723385 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature