VISTA Deficiency Accelerates the Development of Fatal Murine Lupus Nephritis.

ABSTRACT:

Objective

The targeting of negative checkpoint regulators as a means of augmenting antitumor immune responses is now an increasingly used and remarkably effective approach to the treatment of several human malignancies. The negative checkpoint regulator VISTA (V-domain Ig-containing suppressor of T cell activation; also known as programmed death 1 homolog or as death domain 1α) suppresses T cell responses and regulates myeloid activities. We proposed that exploitation of the VISTA pathway is a novel strategy for the treatment of human autoimmune disease, and therefore we undertook this study to determine the impact of VISTA genetic deficiency on lupus development in a lupus-prone mouse strain.

Methods

To evaluate whether genetic deficiency of VISTA affects the development of

SUBMITTER: Ceeraz S 

PROVIDER: S-EPMC5723399 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature