Clinical validation of the normalized mutual information method for registration of CT and MR images in radiotherapy of brain tumors.

ABSTRACT: Image registration integrates information of different imaging modalities and has the potential to improve target volume determination in radiotherapy planning. This paper describes the implementation and validation of a 3D fully automated registration procedure in the process of radiotherapy treatment planning of brain tumors. 15 Patients with various brain tumors received CT and MR brain imaging before the start of radiotherapy. The normalized mutual information (NMI) method was used for image registration. Registration accuracy was estimated by performing statistical analysis of coordinate differences between CT and MR anatomical landmarks along the x-, y- and z-axes. Second, a visual validation protocol was developed to validate the quality of individual registration solutions and this

SUBMITTER: Veninga T 

PROVIDER: S-EPMC5723487 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature