Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.

ABSTRACT:

Introduction

The study investigated the role of neuropathologies in the relationship between TOMM40 '523 genotype and late-life cognitive decline.

Methods

Participants were community-dwelling older persons who had annual cognitive assessments and brain autopsies after death. Genotyping used DNA from peripheral blood or postmortem brain tissue. Linear mixed models assessed the extent to which the association of '523 genotype with cognitive decline is attributable to neuropathologies.

Results

Relative to ε3/ε3 homozygotes with '523-S/VL or '523-VL/VL genotype, both '523-L carriers and ε3/ε3 homozygotes with '523-S/S genotype had faster cognitive decline. The association of '523-L with cognitive decline was attenuated and no longer significant after controlling for Alzhe

SUBMITTER: Yu L 

PROVIDER: S-EPMC5723540 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature