Brain function and structure and risk for incident diabetes: The Atherosclerosis Risk in Communities Study.

ABSTRACT:

Introduction

Diabetes is prospectively associated with cognitive decline. Whether lower cognitive function and worse brain structure are prospectively associated with incident diabetes is unclear.

Methods

We analyzed data for 10,133 individuals with cognitive function testing (1990-1992) and 1212 individuals with brain magnetic resonance imaging (1993-1994) from the Atherosclerosis Risk in Communities cohort. We estimated hazard ratios for incident diabetes through 2014 after adjustment for traditional diabetes risk factors and cohort attrition.

Results

Higher level of baseline cognitive function was associated with lower risk for diabetes (per 1 standard deviation, hazard ratio = 0.94; 95% confidence interval = 0.90, 0.98). This association did not persist after acco

SUBMITTER: Bancks MP 

PROVIDER: S-EPMC5723547 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature