Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study.

ABSTRACT:

Introduction

There may be biologically relevant heterogeneity within typical late-onset Alzheimer's dementia.

Methods

We analyzed cognitive data from people with incident late-onset Alzheimer's dementia from a prospective cohort study. We determined individual averages across memory, visuospatial functioning, language, and executive functioning. We identified domains with substantial impairments relative to that average. We compared demographic, neuropathology, and genetic findings across groups defined by relative impairments.

Results

During 32,286 person-years of follow-up, 869 people developed Alzheimer's dementia. There were 393 (48%) with no domain with substantial relative impairments. Some participants had isolated relative impairments in memory (148, 18%), vis

SUBMITTER: Crane PK 

PROVIDER: S-EPMC5723557 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature