Cost-effectiveness of maternal GBS immunization in low-income sub-Saharan Africa.

ABSTRACT:

Background

A maternal group B streptococcal (GBS) vaccine could prevent neonatal sepsis and meningitis. Its cost-effectiveness in low-income sub-Saharan Africa, a high burden region, is unknown.

Methods

We used a decision tree model, with Markov nodes to project infants' lifetimes, to compare maternal immunization delivered through routine antenatal care with no immunization. 37 countries were clustered on the basis of economic and health resources and past public health performance. Vaccine efficacy for covered serotypes was ranged from 50% to 90%. The model projected EOGBS (early-onset) and LOGBS (late-onset) cases and deaths, disability-adjusted life years (DALYs), healthcare costs (2014 US$), and cost-effectiveness for a representative country in each of the four cluster

SUBMITTER: Russell LB 

PROVIDER: S-EPMC5723707 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature