Oxygen Supplementation Ameliorates Tibial Development via Stimulating Vascularization in Tibetan Chickens at High Altitudes.

ABSTRACT: Tibetan chickens (TBCs) living in high-altitude hypoxic environment, are characterized by delayed growth and small size as compared to low-altitude broiler chickens. Increasing evidences signify the beneficial effect of oxygen (O₂) supplementation in animal's body for regulating their body growth and organ development. However, it is still unclear that whether O₂ supplementation has an ameliorative and protective role in TBCs living at high altitude. In this study, we first found that O₂ supplementation not only increased the survival rate but also promoted the growth of TBCs associated with bone development. Importantly, we observed that the increase of vascular distribution in the tibial hypertrophic zone could contribute to promote growth and development

SUBMITTER: Huang S 

PROVIDER: S-EPMC5723921 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature