1α,25-Dihydroxyvitamin D₃ promotes bone formation by promoting nuclear exclusion of the FoxO1 transcription factor in diabetic mice.

ABSTRACT: 1α,25-Dihydroxyvitamin D₃ (1,25(OH)₂D₃) is the active form of vitamin D, which is responsible for reducing the risk for diabetes mellitus (DM), decreasing insulin resistance, and improving insulin secretion. Previous studies have shown that 1,25(OH)₂D₃ inhibited the activity of FoxO1, which has been implicated in the regulation of glucose metabolism. However, its function and mechanism of action in DM-induced energy disorders and also in bone development remains unclear. Here, using in vitro and in vivo approaches including osteoblast-specific, conditional FoxO1-knock-out mice, we demonstrate that 1,25(OH)₂D₃ ameliorates abnormal osteoblast proliferation in DM-induced oxidative stress conditions and

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC5724012 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature