Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival.

ABSTRACT: Zn plays a key role in controlling macrophage function during an inflammatory event. Cellular Zn homeostasis is regulated by two families of metal transporters, the SLC39A family of importers and the SLC30A family of exporters; however, the precise role of these transporters in maintaining macrophage function is poorly understood. Using macrophage-specific Slc39a10-knockout (Slc39a10^fl/fl;LysM-Cre⁺ ) mice, we found that Slc39a10 plays an essential role in macrophage survival by mediating Zn homeostasis in response to LPS stimulation. Compared with Slc39a10^fl/fl mice, Slc39a10^fl/fl;LysM-Cre⁺ mice had significantly lower mortality following LPS stimulation as we

SUBMITTER: Gao H 

PROVIDER: S-EPMC5724256 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature