A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene.

ABSTRACT: Immune response (Ir) genes, originally proposed by Baruj Benacerraf to explain differential antigen-specific responses in animal models, have become synonymous with the major histocompatibility complex (MHC). We discovered a non-MHC-linked Ir gene in a T cell receptor (TCR) locus that was required for CD8⁺ T cell responses to the Plasmodium berghei GAP50_40-48 epitope in mice expressing the MHC class I allele H-2D^b. GAP50_40-48-specific CD8⁺ T cell responses emerged from a very large pool of naive Vβ8.1⁺ precursors, which dictated susceptibility to cerebral malaria and conferred protection against recombinant Listeria monocytogenes infection. Structural analysis of a prototypical Vβ8.1⁺ TCR-H-2D^b-GAP50

SUBMITTER: Van Braeckel-Budimir N 

PROVIDER: S-EPMC5724374 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature