Functional differences between healthy and diabetic endothelial cells on topographical cues.

ABSTRACT: The endothelial lining of blood vessels is severely affected in type II diabetes. Yet, there is still a paucity on the use of diabetic endothelial cells for study and assessment of implantable devices targeting vascular disease. This critically impairs our ability to determine appropriate topographical cues to be included in implantable devices that can be used to maintain or improve endothelial cell function in vivo. Here, the functional responses of healthy and diabetic human coronary arterial endothelial cells were studied and observed to differ depending on topography. Gratings (2 μm) maintained normal endothelial functions such as adhesiveness, angiogenic capacity and cell-cell junction formation, and reduced immunogenicity of healthy cells. However, a significant and consistent effec

SUBMITTER: Cutiongco MFA 

PROVIDER: S-EPMC5724387 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature