Structural and functional, empirical and modeled connectivity in the cerebral cortex of the rat.

ABSTRACT: Connectomics data from animal models provide an invaluable opportunity to reveal the complex interplay between structure and function in the mammalian brain. In this work, we investigate the relationship between structural and functional connectivity in the rat brain cortex using a directed anatomical network generated from a carefully curated meta-analysis of published tracing data, along with resting-state functional MRI data obtained from a group of 14 anesthetized Wistar rats. We found a high correspondence between the strength of functional connections, measured as blood oxygen level dependent (BOLD) signal correlations between cortical regions, and the weight of the corresponding anatomical links in the connectome graph (maximum Spearman rank-order correlation ρ=0.48). At the network

SUBMITTER: Diaz-Parra A 

PROVIDER: S-EPMC5724396 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature