Clinical significance of circulating immune cells in left- and right-sided colon cancer.

ABSTRACT:

Background

Left-sided and right-sided colon cancers (LCCs and RCCs, respectively) differ in their epidemiology, pathogenesis, genetic and epigenetic alterations, molecular pathways and prognosis. Notably, immune response gene expression profiles have been shown to differ between patients with LCC and patients with RCC. The immune system plays an important role in tumor immunosurveillance, and there is increasing evidence that peripheral blood immune cells have a profound influence on tumor prognosis. This study aimed to determine the clinical significance of circulating immune cells with respect to colon tumor locations.

Methods

Different types of circulating immune cells were separated and analysed based on their surface markers by flow cytometry. We compared the numbers of

SUBMITTER: Di J 

PROVIDER: S-EPMC5724405 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature