Association of a 3' untranslated region polymorphism in proprotein convertase subtilisin/kexin type 9 with HIV viral load and CD4+ levels in HIV/hepatitis C virus coinfected women.

ABSTRACT:

Objective

To assess variation in genes that regulate cholesterol metabolism in relation to the natural history of HIV infection.

Design

Cross-sectional and longitudinal analysis of the Women's Interagency HIV Study.

Methods

We examined 2050 single nucleotide polymorphisms (SNPs) in 19 genes known to regulate cholesterol metabolism in relation to HIV viral load and CD4 T-cell levels in a multiracial cohort of 1066 antiretroviral therapy-naive women.

Results

Six SNPs were associated with both HIV viral load and CD4 T-cell levels at a false discovery rate of 0.01. Bioinformatics tools did not predict functional activity for five SNPs, located in introns of nuclear receptor corepressor 2, retinoid X receptor alpha (RXRA), and tetratricopeptide repeat domain 39B. Rs

SUBMITTER: Kuniholm MH 

PROVIDER: S-EPMC5724557 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature