Electrical stimulation of gut motility guided by an in silico model.

ABSTRACT:

Objective

Neuromodulation of the central and peripheral nervous systems is becoming increasingly important for treating a diverse set of diseases-ranging from Parkinson's Disease and epilepsy to chronic pain. However, neuromodulation of the gastrointestinal (GI) tract has achieved relatively limited success in treating functional GI disorders, which affect a significant population, because the effects of stimulation on the enteric nervous system (ENS) and gut motility are not well understood. Here we develop an integrated neuromechanical model of the ENS and assess neurostimulation strategies for enhancing gut motility, validated by in vivo experiments.

Approach

The computational model included a network of enteric neurons, smooth muscle fibers, and interstitial cells of Caj

SUBMITTER: Barth BB 

PROVIDER: S-EPMC5724779 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature