Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure.

ABSTRACT: In humans and rodents, stress promotes habit-based behaviors that can interfere with action-outcome decision-making. Further, developmental stressor exposure confers long-term habit biases across rodent-primate species. Despite these homologies, mechanisms remain unclear. We first report that exposure to the primary glucocorticoid corticosterone (CORT) in adolescent mice recapitulates multiple neurobehavioral consequences of stressor exposure, including long-lasting biases towards habit-based responding in a food-reinforced operant conditioning task. In both adolescents and adults, CORT also caused a shift in the balance between full-length tyrosine kinase receptor B (trkB) and a truncated form of this neurotrophin receptor, favoring the inactive form throughout multiple corticolimbic brai

SUBMITTER: Barfield ET 

PROVIDER: S-EPMC5724896 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature