Dynamical compensation and structural identifiability of biological models: Analysis, implications, and reconciliation.

ABSTRACT: The concept of dynamical compensation has been recently introduced to describe the ability of a biological system to keep its output dynamics unchanged in the face of varying parameters. However, the original definition of dynamical compensation amounts to lack of structural identifiability. This is relevant if model parameters need to be estimated, as is often the case in biological modelling. Care should we taken when using an unidentifiable model to extract biological insight: the estimated values of structurally unidentifiable parameters are meaningless, and model predictions about unmeasured state variables can be wrong. Taking this into account, we explore alternative definitions of dynamical compensation that do not necessarily imply structural unidentifiability. Accordingly, we sho

SUBMITTER: Villaverde AF 

PROVIDER: S-EPMC5724898 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature