Infant Gut Microbiome Associated With Cognitive Development.

ABSTRACT:

Background

Studies in rodents provide compelling evidence that microorganisms inhabiting the gut influence neurodevelopment. In particular, experimental manipulations that alter intestinal microbiota impact exploratory and communicative behaviors and cognitive performance. In humans, the first years of life are a dynamic time in gut colonization and brain development, but little is known about the relationship between these two processes.

Methods

We tested whether microbial composition at 1 year of age is associated with cognitive outcomes using the Mullen Scales of Early Learning and with global and regional brain volumes using structural magnetic resonance imaging at 1 and 2 years of age. Fecal samples were collected from 89 typically developing 1-year-olds. 16S ribosomal

SUBMITTER: Carlson AL 

PROVIDER: S-EPMC5724966 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature